Female oral contraceptive is by inhibiting ovulation and achieve the purpose of contraception, is also currently one of the most widely used contraceptive methods. However, contraception in the process, women will suffer from a variety of diseases, once ill, it will inevitably have to take some medicine. Clinical practice has shown that contraceptive when used in conjunction with many drug interactions can occur, resulting in many adverse reactions. Therefore, women who take birth control pills, you should avoid using the following drugs, when the non-use of drugs is not available, should use other methods of contraception.
1. antibiotics: number of broad-spectrum antibiotics such as ampicillin, tetracycline, long-term use can suppress the growth of intestinal bacteria, reducing the enterohepatic circulation of estrogen in the body, can make contraceptives reduce the concentration of, reduced contraceptive effectiveness. Therefore, women taking birth control pills should not in general use of antibiotics, if the illness takes a long time when you use antibiotics, it is best to switch to other methods of contraception.
2. anti-TB drugs rifampicin: effect of rifampicin on drug metabolizing enzyme induction, will accelerate the metabolism of contraceptive pills, reduce the effective concentration of contraceptives in the plasma, can lead to contraceptive failure. Therefore, when taking rifampicin combating tuberculosis, dose should be used by other methods of contraception or birth control pills double.
3. anti-epilepsy drug phenytoin sodium: Epilepsy patients taking phenytoin sodium, not oral contraceptives, otherwise it will cause fluid retention, are in danger of induced seizures.
4. sleeping pills miltown: miltown, sodium phenobarbital, secobarbital and other sleeping pills with enzymatic action, will reduce the effectiveness of oral contraceptives. Therefore, when you need to use sleeping pills, the choice of stability.
5. the antirheumatic drug phenylbutazone: oral contraceptives for women, if taking phenylbutazone is needed due to suffering from rheumatism, may result in contraceptive failure. Because phenylbutazone with enzymatic action, can accelerate metabolism of drugs, can make its efficacy to reduce contraceptive failure as a result. Therefore, when the treatment of rheumatic diseases rise as the main status, or the amount of oral contraceptives should be stopped, or to take other contraceptive methods.
6. corticosteroid drugs: oral contraceptives can increase cortical hormone drugs (such as prednisone, dexamethasone and other) effects, slow down their metabolism, so that their effects and side effects have been enhanced. Therefore, both at the same time taking the time, you must reduce the use of corticosteroid drug dose.
7. the anti-hypertensive drug reserpine: oral contraceptives containing estrogen, with enhanced reserpine, methyldopa stimulating effects of milk secretion, can cause hyperplasia of mammary glands and lactation. In addition, chlorpromazine, imipramine and other antipsychotics, similar effects can also occur. Therefore, women taking birth control pills should avoid the use of these drugs.
8. the tricyclic antidepressants: imipramine is a Tricyclic Antidepressant, and at the same time taking oral contraceptives, to compete in the liver of common metabolic enzymes and metabolism of antidepressant drugs in the body slows, extend the time. Therefore, when you take the two, should reduce the use of Tricyclic Antidepressant doses.
9. the anticoagulant drugs: anticoagulant drugs (such as dual coumarin class) can suppress the prothrombin and synthesis of coagulation factors in the body, but contraceptives can make it to increase, thereby reducing the double effects of coumarin drugs, it is not appropriate in the treatment during the use of the contraceptive pill.
10. insulin: contraceptives can promote the deterioration of diabetes, increase patient\'s need for insulin production (additional 8-20 units a day), and may increase the incidence of diabetes patients complicated with cardiovascular disease. Therefore, contraception should not be used in patients with diabetes drugs.
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